The Science Behind Sperm Donor and Recipient Matchmaking

* found that sperm viability was associated with partners' HLA dissimilarity, indicating that cervical mucus may selectively facilitate later gamete fusion between immunogenetically compatible partners .

Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J and Kekäläinen J (2020) Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function Proc Biol Sci., doi: 10.1098/rspb.2020.1682. Epub 2020 Aug 19.

* found an increased frequency of homozygosity for HLA-E*0101 in Egyptian women with RM

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* proposed a genetic-risk calculation that could predict recurrent miscarriage (RM) based on analysing HLA haplotypes from couples either with histories of successful pregnancies or RM .

Mora-Sánchez A, Aguilar-Salvador D, Nowak I (2019) Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage NPJ Digit Med Mar 7;2:12. doi: 10.1038/s41746-019-0089-x

* performed a meta-analyses of 41 studies and showed that HLA-B sharing and HLA-DR sharing were both associated with the occurrence of RM .

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* identified differential association of alleles in HLA-A, HLA-B, HLA-C, and HLA-DRB1 when compared with reported world RSA patients .

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* describe the relationship between HLA similarity at individual alleles, as well as HLA haplotypes as indicators for increased risk of fetal loss among Hutterite couples .

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* results of a 10 year study that demonstrated increased fetal loss rates among Hutterite couples matching for HLA antigens .

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* demonstrated increased rates of recurrent spontaneous abortion among Hutterite couples matching for HLA-DQA1 alleles

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Dandine-Roulland C, Laurent R, Dall'Ara I, Toupance B and Chaix R (2019) Genomic evidence for MHC disassortative mating in humans

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Sherlock JM, Sidari MJ, Harris EA, Barlow FK, Zietsch BP (2016) Testing the mate-choice hypothesis of the female orgasm: disentangling traits and behaviours . Socioaffect Neurosci Psychol. 6:31562.

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Wedekind C (2006) The Intensity of Human Body Odors and the MHC: Should We Expect A Link ? Evolutionary Psychology. 4:85-94

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