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Vetenskaplig analys
Baserat pÄ referentgranskad genetisk forskning.
Gene Pool Science
The Science Behind Gene Pool
Gene Pool uses genetic compatibility analysis and stable matching to help donors, recipients, and co-parents make informed decisions about family-building.
Genetisk Kompatibilitetsmatchning
Gene Pool uses advanced genetic analysis to evaluate compatibility between donors and recipients. The matching model analyzes key genetic markers so families can make decisions with clearer biological context.
By analyzing DNA data from genetic testing services, Gene Pool can identify compatibility factors that traditional donor-search methods may miss.
HLA-kompatibilitet
Human Leukocyte Antigens (HLA) play a crucial role in immune system function and have been linked to successful pregnancies. Gene Pool analyzes HLA markers to help identify donors with favorable genetic compatibility.
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KompatibilitetspoÀng
Tydliga mÄtt för att vÀgleda familjebildningsbeslut.
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Familjeplanering
Stödja resan till förÀldraskap med bÀttre sammanhang.
Forskningbaserat tillvÀgagÄngssÀtt
The Gene Pool matching model is grounded in peer-reviewed research across genetics, immunology, reproductive biology, and mate-choice science.
Jokiniemi et al., 2025
Visade att kvinnliga reproduktionskanalen selektivt aktiverar spermier baserat pÄ MHC-kompatibilitet, vilket ger bevis för kryptiskt kvinnligt partnerval pÄ cellulÀr nivÄ.
Jokiniemi A, Turunen T, Kohonen M et al. (2025) Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans. Heredity 134, 321-330.
View SourceJokiniemi et al., 2020
Fann att spermiernas viabilitet var associerad med partners HLA-olikhet, vilket indikerar att livmoderhalsslem kan selektivt underlÀtta senare gametsammansmÀltning mellan immunogenetiskt kompatibla partners.
Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J and Kekalainen J (2020) Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function. Proc Biol Sci., doi: 10.1098/rspb.2020.1682.
View SourceMeuleman et al., 2015
Systematisk granskning och metaanalys som bekrÀftar sambandet mellan HLA-delning och upprepade missfall i flera populationer.
Meuleman T, Lashley LE, Dekkers OM, van Lith J, Claas FH and Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis. Hum Immunol. May;76(5):362-73.
View SourceMora-Sanchez et al., 2019
Föreslog en genetisk riskberÀkning som kunde förutsÀga upprepade missfall genom att analysera HLA-haplotyper frÄn par med lyckade graviditeter eller upprepade missfall.
Mora-Sanchez A, Aguilar-Salvador D, Nowak I (2019) Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage. NPJ Digit Med Mar 7;2:12.
View SourceOber, 1999
Banbrytande studie om HLA, fertilitet och partnerval i ett mÀnskligt isolat, som visar sambandet mellan HLA-kompatibilitet och reproduktionsresultat.
Ober C (1999) Studies of HLA, fertility and mate choice in a human isolate. Hum Reprod Update 5(2):103-107.
View SourceOber et al., 1998
Prospektiv studie av matchning av humana leukocytantigener och fosterdöd.
Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW (1998) Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. Human Reproduction, Volume 13, Issue 1, Pages 33-38.
View SourceOber et al., 1993
Visade ökad upprepad spontan abort bland par som matchar HLA-DQA1-alleler.
Ober, Steck, Ven, Billstrand, Messer, Kwak, Beaman, Beer (1993) MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. Journal of Reproductive Immunology, Volume 25, Issue 3, Pages 195-207.
View SourceHavlicek et al., 2020
Recenserar preferenser för lukter associerade med det stora histokompatibilitetskomplexet och mÀnskligt partnerval över nÀra och avlÀgsna forskningshorisonter.
Havlicek J, Winternitz J, Roberts S (2020) Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons. Philosophical Transactions of the Royal Society B, 375:20190260.
View SourceStabil matchningsalgoritm
2012 Ă„rs Nobelpris i ekonomi
Gene Pool employs the Gale-Shapley algorithm , a Nobel Prize-winning mathematical approach to stable matching. In 2012, Lloyd Shapley and Alvin Roth received the Nobel Memorial Prize in Economic Sciences for the theory of stable allocations and the practice of market design.
The algorithm keeps matches stable, meaning donors and recipients are optimally matched based on mutual compatibility criteria. This approach is used worldwide to match organ donors with recipients, students with schools, and medical residents with hospitals.
Nobelpriset 2012Matematiskt bevisad
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