01
科学分析
基于同行评审的遗传研究。
基因池科学
基因库背后的科学
Gene Pool uses genetic compatibility analysis and stable matching to help donors, recipients, and co-parents make informed decisions about family-building.
基因兼容性匹配
Gene Pool uses advanced genetic analysis to evaluate compatibility between donors and recipients. The matching model analyzes key genetic markers so families can make decisions with clearer biological context.
By analyzing DNA data from genetic testing services, Gene Pool can identify compatibility factors that traditional donor-search methods may miss.
HLA 兼容性
Human Leukocyte Antigens (HLA) play a crucial role in immune system function and have been linked to successful pregnancies. Gene Pool analyzes HLA markers to help identify donors with favorable genetic compatibility.
02
兼容性评分
清晰的指标来指导家庭建设决策。
03
家庭计划
通过更好的背景支持育儿之旅。
基于研究的方法
The Gene Pool matching model is grounded in peer-reviewed research across genetics, immunology, reproductive biology, and mate-choice science.
Jokiniemi 等人，2025
证明女性生殖道有选择性地激活基于MHC兼容性的精子，为细胞水平上的隐性女性配偶选择提供证据。
Jokiniemi A, Turunen T, Kohonen M et al. (2025) Female-mediated selective sperm activation may remodel major histocompatibility complex-based mate choice decisions in humans. Heredity 134, 321-330.
查看来源Jokiniemi et al., 2020
发现精子活力与伴侣的HLA异质性相关，表明宫颈粘液可能选择性地促进免疫遗传学兼容的伴侣之间的后续配子融合。
Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J and Kekalainen J (2020) Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function. Proc Biol Sci., doi: 10.1098/rspb.2020.1682.
查看来源Meuleman et al., 2015
系统性回顾和荟萃分析证实了在多个群体中HLA共享与复发性流产之间的关联。
Meuleman T, Lashley LE, Dekkers OM, van Lith J, Claas FH and Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis. Hum Immunol. May;76(5):362-73.
查看来源Mora-Sanchez et al., 2019
提出了一种遗传风险计算方法，可以通过分析成功妊娠或复发性流产夫妇的HLA单倍型来预测复发性流产。
Mora-Sanchez A, Aguilar-Salvador D, Nowak I (2019) Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage. NPJ Digit Med Mar 7;2:12.
查看来源Ober, 1999
关于人类分离群体的HLA、生育能力和配偶选择的里程碑式研究，证明了HLA相容性与生殖结果之间的联系。
Ober C (1999) Studies of HLA, fertility and mate choice in a human isolate. Hum Reprod Update 5(2):103-107.
查看来源Ober et al., 1998
人类白细胞抗原匹配与胎儿丢失的前瞻性研究。
Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW (1998) Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. Human Reproduction, Volume 13, Issue 1, Pages 33-38.
查看来源Ober et al., 1993
证明了HLA-DQA1等位基因匹配的夫妇中复发性自然流产的增加。
Ober, Steck, Ven, Billstrand, Messer, Kwak, Beaman, Beer (1993) MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. Journal of Reproductive Immunology, Volume 25, Issue 3, Pages 195-207.
查看来源Havlicek et al., 2020
回顾了主要组织相容性复合体相关的气味偏好和人类在远近研究范围内的配偶选择。
Havlicek J, Winternitz J, Roberts S (2020) Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons. Philosophical Transactions of the Royal Society B, 375:20190260.
查看来源稳定匹配算法
2012年诺贝尔经济学奖
基因池采用 盖尔-沙普利算法 , a Nobel Prize-winning mathematical approach to stable matching. In 2012, Lloyd Shapley and Alvin Roth received the Nobel Memorial Prize in Economic Sciences for the theory of stable allocations and the practice of market design.
The algorithm keeps matches stable, meaning donors and recipients are optimally matched based on mutual compatibility criteria. This approach is used worldwide to match organ donors with recipients, students with schools, and medical residents with hospitals.
2012年诺贝尔奖数学证明